Article
A de novo protein binding pair by computational design and directed evolution.
Molecular cell - 22 Apr 2011
Karanicolas John, Corn Jacob E, Chen Irwin, Joachimiak Lukasz A, Dym Orly, Peck Sun H, Albeck Shira, Unger Tamar, Hu Wenxin, Liu Gaohua, Delbecq Scott, Montelione Gaetano T, Spiegel Clint P, Liu David R, Baker David
Abstract excerpt
The de novo design of protein-protein interfaces is a stringent test of our understanding of the principles underlying protein-protein interactions and would enable unique approaches to biological and medical challenges. Here we describe a motif-based method to computationally design protein-protein complexes with native-like interface composition and interaction density. Using this method we designed a pair of...
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