Article

Identification of Computationally Designed Skeletal and Cardiac Promoters with High Specificity Across AAV Delivery Routes

2026-01-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Precise control of transgene expression is essential for safe and effective AAV gene therapies. While capsid engineering has advanced tissue targeting, progress in developing regulatory elements that confine expression to specific tissues has lagged. This gap limits the ability to minimize off-target expression and associated safety risks, emphasizing the need...

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Literature Corpus work: f10b1af0-e8f3-5fb3-92d7-2435537497df
DOI: 10.21203/rs.3.rs-8504031/v1

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