Article
RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3.
Gastroenterology - 1 Nov 2020
Karmakar Saswati, Rauth Sanchita, Nallasamy Palanisamy, Perumal Naveenkumar, Nimmakayala Rama Krishna, Leon Frank, Gupta Rohitesh, Barkeer Srikanth, Venkata Ramakanth Chirravuri, Raman Venu, Rachagani Satyanarayana, Ponnusamy Moorthy P, Batra Surinder K
Abstract excerpt
BACKGROUND & AIMS: It is not clear how pancreatic cancer stem cells (CSCs) are regulated, resulting in ineffective treatments for pancreatic cancer. PAF1, a RNA polymerase II-associated factor 1 complex (PAF1C) component, maintains pluripotency of stem cells, by unclear mechanisms, and is a marker of CSCs. We investigated mechanisms by which PAF1 maintains CSCs and contributes to development of pancreatic tumors....
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