Article
Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size.
Molecular biology and evolution - 1 Jun 2017
Konrad Anke, Thompson Owen, Waterston Robert H, Moerman Donald G, Keightley Peter D, Bergthorsson Ulfar, Katju Vaishali
Abstract excerpt
Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to determine the dynamics of spontaneous mitochondrial mutations in small populations in the absence and presence of selection, we evolved mutation accumulation (MA) lines of Caenorhabditis elegans in parallel over 409 consecutive...
Topics
- Animals
- Biological Evolution
- Caenorhabditis elegans
- DNA, Mitochondrial
- Evolution, Molecular
- Genome, Mitochondrial
- Mitochondria
- Mutation
- Mutation Accumulation
- Mutation Rate
- Phylogeny
- Phylogeography
- Population Density