Article

PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

2019-03-13

Abstract excerpt

In multiple species, certain tissue types are prone to acquiring greater loads of mitochondrial genome (mtDNA) mutations relative to others, however the mechanisms that drive these heteroplasmy differences are unknown. We found that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required for mitochondrial autophagy (mitophagy), underlie stere...

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Literature Corpus work: 7cf0b1bb-78eb-5ca7-a772-09d88ceb75e6
DOI: 10.1101/576165

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