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PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

1 Jun 2021

Abstract excerpt

In multiple species, certain tissue types are prone to acquiring greater loads of mitochondrial genome (mtDNA) mutations relative to others, but the mechanisms that drive these heteroplasmy differences are unknown. We find that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required for mitochondrial autophagy (mitophagy), underlie...

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PMID: 34077728
DOI: 10.1016/j.celrep.2021.109203

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