Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor.

Abstract excerpt

Most ligand-gated channels exhibit desensitization, which is the progressive fading of ionic current in the prolonged presence of agonist. This process involves conformational changes that close the channel despite continued agonist binding. Despite the physiological and pathological importance of desensitization, little is known about the conformational changes that underlie this process in any Cys-loop ion...

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