Article
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
19 Sept 2003
Abstract excerpt
The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive prostate cancer. Here we investigate the functional role of EZH2 in cancer cell invasion and breast cancer progression. EZH2 transcript and protein were consistently elevated in invasive breast carcinoma compared with normal breast epithelia. Tissue microarray analysis, which...
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