Article

ATM-deficiency induced microglial activation promotes neurodegeneration in Ataxia-Telangiectasia

2021-09-09

Abstract excerpt

While ATM loss-of-function has long been identified as the genetic cause of Ataxia Telangiectasia (A-T), how this genetic mutation leads to selective and progressive degeneration of cerebellar Purkinje and granule neurons remains unclear. ATM expression is enriched in microglia, the resident immune cell of the central nervous system, throughout cerebellar development and adulthood. Microglial activation has been...

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Literature Corpus work: a8f9fda6-9085-58a9-b206-cdfff682c950
DOI: 10.1101/2021.09.09.459619

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