Article

Distinct prostate cancer neuroendocrine subtypes predict prognosis and guide personalized prostate-specific membrane antigen-targeted therapy

2024-09-30

Abstract excerpt

<h4>Background and Objective</h4> Second-generation hormonal therapy inhibits castration-resistant prostate cancer (CRPC), but the tumor eventually recurs as neuroendocrine prostate cancer (NEPC) and turns lethal. Differentiating lineage plasticity that contributed to distinct NEPC subtypes aids in advancing treatments, particularly the recent FDA-approved 177 Lu-PSMA-617 radiopharmaceutical therapy. <h4>Method...

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Literature Corpus work: 1028d7f2-c4ac-5b24-8fed-42b84a6506a7
DOI: 10.1101/2024.09.28.615561

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