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Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer

2 Apr 2024

Abstract excerpt

To resist lineage-dependent therapies such as androgen receptor inhibition, prostate luminal epithelial adenocarcinoma cells often adopt a stem-like state resulting in lineage plasticity and phenotypic heterogeneity. Castrate-resistant prostate adenocarcinoma can transition to neuroendocrine (NE) and occasionally to amphicrine, co-expressed luminal and NE, phenotypes. We developed castrate-resistant prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38563224
DOI: 10.1093/stmcls/sxae025

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