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The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches

1 Apr 2021

Abstract excerpt

The use of androgen deprivation therapy and second-line anti-androgens in prostate cancer has led to the emergence of tumors employing multiple androgen receptor (AR)-dependent and AR-independent mechanisms to resist AR-targeted therapies in castration-resistant prostate cancer (CRPC). While the AR signaling axis remains the cornerstone for therapeutic development in CRPC, a clearer understanding of the...

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PMID: 33792558
DOI: 10.1530/erc-21-0002

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