Article

Molecular Dynamics Study of Cl- Permeation through Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

2021-08-13

Abstract excerpt

<title>Abstract</title> <p>The recent elucidation of atomistic structures of Cl - channel CFTR provides opportunities for understanding the molecular basis of cystic fibrosis. Despite having been activated through phosphorylation and provided with ATP ligands, several near-atomistic cryo-EM structures of CFTR are in a closed state, as inferred from the lack of a continuous passage through a hydrophobic bottleneck...

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Literature Corpus work: a8d7e970-24eb-5ecb-bc11-8482871adceb
DOI: 10.21203/rs.3.rs-771352/v1

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