Article

Cryo-EM visualization of an active high open probability CFTR ion channel

2018-03-02

Abstract excerpt

The Cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, crucial to epithelial salt and water homeostasis, and defective due to mutations in its gene in patients with cystic fibrosis is a unique member of the large family of ATP-binding cassette transport proteins. Regulation of CFTR channel activity is stringently controlled by phosphorylation and nucleotide binding. Structural changes that u...

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Literature Corpus work: 9f3dd2cc-269b-58fe-8f5c-6b1c0ed4e33c
DOI: 10.1101/274316

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