Article

Structural comparative modeling of multi-domain ΔF508 CFTR

2021-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Cystic Fibrosis (CF) is a common genetic disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel expressed in several vital organs. Absence of functional CFTR results in imbalanced osmotic equilibrium and subsequent mucus build up in the lungs - which increases the risk of infection and eventually causes death. CFTR is an ATP bin...

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Literature Corpus work: 97f00494-1512-5a37-a5e1-32db83229218
DOI: 10.1101/2021.11.17.468921

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