Article
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.
Cell - 1 Dec 2016
Zhang Zhe, Chen Jue
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel evolved from the ATP-binding cassette (ABC) transporter family. In this study, we determined the structure of zebrafish CFTR in the absence of ATP by electron cryo-microscopy to 3.7 Å resolution. Human and zebrafish CFTR share 55% sequence identity, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical....
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