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Article

A repertoire library that allows the selection of synthetic SH2s with altered binding specificities.

Oncogene - 23 Aug 2001

Malabarba M G, Milia E, Faretta M, Zamponi R, Pelicci P G, Di Fiore P P

Abstract excerpt

Tyrosine phosphorylation is one of the major mechanisms involved in the intracellular propagation of external signals. Strategies aimed at interfering with this process might allow the control of several cellular phenotypes. SH2 domains mediate protein-protein interactions by recognizing phosphotyrosine (pY) residues in the context of specific phosphopeptides. We created an SH2-scaffolded repertoire library by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11526507
DOI: 10.1038/sj.onc.1204654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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