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Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner

2020-04-28

Abstract excerpt

Primary cilia are sensory organelles built and maintained by intraflagellar transport (IFT) multi-protein complexes. Deletion of different IFT-B genes attenuates polycystic kidney disease (PKD) severity in juvenile and adult Autosomal Dominant (AD) PKD mouse models, while deletion of an IFT-A adaptor, Tulp3 , attenuates PKD severity in adult mice only. These studies indicate that dysfunction of specific cilia com...

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Identifiers and source

Literature Corpus work
c8d36a50-2e42-5eee-80a2-eeaded327480
DOI
10.1101/2020.04.26.061796
Open publication

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Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent mannerDOI 10.1101/2020.04.26.061796
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