Article

Using phage display for rational engineering of a higher affinity humanized 3’phosphohistidine-specific antibody

2024-11-04

Abstract excerpt

Histidine phosphorylation (pHis) is a non-canonical post-translational modification (PTM) that is historically understudied due to a lack of robust reagents that are required for its investigation, such as high affinity pHis-specific antibodies. Engineering pHis-specific antibodies is very challenging due to the labile nature of the phosphoramidate (P-N) bond and the stringent requirements for selective recognitio...

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Literature Corpus work: a8c550a2-c94f-5374-a2fa-e98d62c4d3bd
DOI: 10.1101/2024.11.04.621849

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