Article

Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif

2018-11-06

Abstract excerpt

Phosphotyrosine (pY) is one of the most highly studied posttranslational modifications that is responsible for tightly regulating many signaling pathways in eukaryotes. Pan-specific pY antibodies have emerged as powerful tools for understanding the role of these modifications. Nevertheless, structures have not been reported for pan-specific pY antibodies, greatly impeding the further development of tools for integ...

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Literature Corpus work: b8e43dbe-5739-5977-8d28-fb10c785878c
DOI: 10.1021/jacs.8b08402

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