Article

Ribo-seq guided design of enhanced protein secretion in <i>Komagataella phaffii</i>

2025-02-16

Abstract excerpt

The production of recombinant proteins requires the precise coordination of various biological processes, including protein synthesis, folding, trafficking, and secretion. The overproduction of a heterologous protein can impose various bottlenecks on these networks. Identifying and alleviating these bottlenecks can guide strain engineering efforts to enhance protein production. The methylotrophic yeast Komagatael...

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Literature Corpus work: a8c53456-95ab-5ee7-8c92-671eb71274c4
DOI: 10.1101/2025.02.12.637931

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