Article
Comparative genomics and transcriptomics of Pichia pastoris.
BMC genomics - 5 Aug 2016
Love Kerry R, Shah Kartik A, Whittaker Charles A, Wu Jie, Bartlett M Catherine, Ma Duanduan, Leeson Rachel L, Priest Margaret, Borowsky Jonathan, Young Sarah K, Love J Christopher
Abstract excerpt
BACKGROUND: Pichia pastoris has emerged as an important alternative host for producing recombinant biopharmaceuticals, owing to its high cultivation density, low host cell protein burden, and the development of strains with humanized glycosylation. Despite its demonstrated utility, relatively little strain engineering has been performed to improve Pichia, due in part to the limited number and inconsistent...
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