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Ongoing evolution of the <i>Mycobacterium tuberculosis</i> lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

2023-10-09

Abstract excerpt

The bacterial determinants that facilitate Mycobacterium tuberculosis (Mtb) adaptation to the human host environment are poorly characterized. We have sought to decipher the pressures facing the bacterium in vivo by assessing Mtb genes that are under positive selection in clinical isolates. One of the strongest targets of selection in the Mtb genome is lldD2 , which encodes a quinone-dependent L-lactate dehydro...

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Literature Corpus work
a8a334f4-ac61-5752-bf9e-c4ddb4bfe21d
DOI
10.1101/2023.10.09.561592
Open publication

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Ongoing evolution of the <i>Mycobacterium tuberculosis</i> lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressureDOI 10.1101/2023.10.09.561592
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