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Article

Understanding the role of pyruvate dehydrogenase in Listeria monocytogenes virulence.

Infection and immunity - 14 Jul 2026

Freeman Matthew J, Eral Noah J, Debrine Abigail M, Stevenson David M, Amador-Noguez Daniel, Sauer John-Demian

Abstract excerpt

Bacterial pathogens must possess finely tuned physiological adaptations to adapt to their infectious niche. One such niche inhabited by Listeria monocytogenes (L. monocytogenes) is the host cell cytosol, a compartment characterized by significant barriers to entry, metabolic limitation, and immune surveillance. Previously, we identified L. monocytogenes transposon mutants defective for intracellular survival due...

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PMID: 42214391
DOI: 10.1128/iai.00505-25
PMCID: PMC13367045

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PTS

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