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Mycolic acid and cholesterol induced transcriptomic adaptations in wild type and Mce complex ATPase subunit deleted strain of <i>M. tuberculosis</i> H37Rv

2024-05-13

Abstract excerpt

During infection and latency, Mycobacterium tuberculosis (Mtb) primarily relies on lipids as its main energy source. The Mtb mammalian cell entry (Mce) complexes function as lipid transporters with Mkl as the ATPase subunit for substrate translocation. Cholesterol and mycolic acid are essential to the infectiousness and pathogenicity of Mtb. Here, we have investigated the transcriptomic responses of wild type and...

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Literature Corpus work
020350ad-b7af-5460-8494-0df8d04b60fd
DOI
10.1101/2024.05.13.593965
Open publication

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