Article

Early developmental characterization of gap-induced prepulse inhibition and habituation in the Fragile X Syndrome mouse model

2025-10-14

Abstract excerpt

<h4>Introduction</h4> Atypical sensory processing, particularly auditory hypersensitivity, is a common and debilitating phenotype of Fragile X Syndrome (FXS). Electrophysiology studies in FMR1- knockout (KO) mice previously observed hyperexcitability at the auditory cortex (AC), with enhanced neuronal firing to auditory stimuli. Prepulse inhibition (PPI), a behavioral measure of sensorimotor gating, is robustly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a870c0d8-e231-5b99-a4dc-abb36e9d68ca
DOI: 10.1101/2025.10.13.682100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early developmental characterization of gap-induced prepulse inhibition and habituation in the Fragile X Syndrome mouse modelDOI 10.1101/2025.10.13.682100Read

Alterations in auditory midbrain processing is observed in both female and male mouse model of Fragile X SyndromeSemantic proximity Read

Altered auditory maturation in Fragile X syndrome and its involvement in audiogenic seizure susceptibilitySemantic proximity Read

Fragile X mice develop sensory hyperreactivity to auditory stimuli.Semantic proximity Read

Auditory Hypersensitivity and Processing Deficits in a Rat Model of Fragile X SyndromeSemantic proximity Read

Early auditory sensory processing deficits in mouse mutants with reduced NMDA receptor function.Semantic proximity Read

Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice.Semantic proximity Read

Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome.Semantic proximity Read

Neural response to repeated auditory stimuli and its association with early language development in children with Fragile X syndromeSemantic proximity Read

Hypoplasticity in sensory-driven necortical circuits of Fragile X miceSemantic proximity Read

Auditory Brainstem Responses in the C57BL/6J Fragile X Syndrome Knockout Mouse ModelSemantic proximity Read

Hyperexcitability in the olfactory bulb and impaired fine odor discrimination in the <i>Fmr1</i> KO mouse model of fragile X syndromeSemantic proximity Read

Astrocytic contribution to auditory hypersensitivity in a mouse model of fragile X syndromeSemantic proximity Read