Article
Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice.
Molecular psychiatry - 1 Apr 2004
Frankland P W, Wang Y, Rosner B, Shimizu T, Balleine B W, Dykens E M, Ornitz E M, Silva A J
Abstract excerpt
Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting cognitive and behavioral function in humans. This syndrome is characterized by a cluster of abnormalities including lower IQ, attention deficits, impairments in adaptive behavior and increased incidence of autism. Here, we show that young males with FXS have profound deficits in prepulse inhibition (PPI), a basic marker of...
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