Article
Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.
Cerebral cortex (New York, N.Y. : 1991) - 4 Jun 2025
Xu Fei, Chen Guangdi, Jeon Shin, Ling Lynne, Manohar Senthilvelan, Ding Dalian, Auerbach Benjamin D, Lee Jae, Lee Soo-Kyung, Sun Wei
Abstract excerpt
FOXG1 syndrome (FS) is a rare and devastating neurodevelopmental disorder affected by FOXG1 gene mutations and reduced sound tolerance has been reported in children with FS. Effects of single missense mutation of Foxg1 gene on auditory function and behavior were studied using the G216S mouse model. G216S mice showed significantly reduced gap-induced prepulse inhibition, suggesting poor temporal processing without...
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- Animals
- Auditory Cortex
- Forkhead Transcription Factors
- Nerve Tissue Proteins
- Acoustic Stimulation
- Mice