Article
Structural insights into the mechanism of phosphate recognition and transport by XPR1.
Nature communications - 2 Jan 2025
Zhang Wenhui, Chen Yanke, Guan Zeyuan, Wang Yong, Tang Meng, Du Zhangmeng, Zhang Jie, Cheng Meng, Zuo Jiaqi, Liu Yan, Wang Qiang, Liu Yanjun, Zhang Delin, Yin Ping, Ma Ling, Liu Zhu
Abstract excerpt
XPR1 is the sole protein known to transport inorganic phosphate (Pi) out of cells, a function conserved across species from yeast to mammals. Human XPR1 variants lead to cerebral calcium-phosphate deposition and primary familial brain calcification (PFBC), a hereditary neurodegenerative disorder. Here, we present the cryo-EM structure of human XPR1 in both its Pi-unbound and various Pi-bound states. XPR1 features...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.