Article

Structural insights into the mechanism of phosphate recognition and transport by human XPR1

2024-08-20

Abstract excerpt

XPR1 is the only known protein responsible for transporting inorganic phosphate (Pi) out of cells, a function conserved from yeast to mammals. Human XPR1 variants lead to cerebral calcium-phosphate deposition, which are associated with a hereditary neurodegenerative disorder known as primary familial brain calcification (PFBC). Here, we present the cryo-EM structure of human XPR1 in both its Pi-unbound form and va...

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Literature Corpus work: 110039bd-78d1-5499-aad1-7d152af827ad
DOI: 10.1101/2024.08.19.608714

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