Article

Structural insights into the mechanism of phosphate recognition and transport by human XPR1

2024-08-29

Abstract excerpt

<title>Abstract</title> <p>XPR1 is the only known protein that transports inorganic phosphate (Pi) out of cells, and the function is conserved across species from yeast to mammals<sup>1-4</sup>. Human XPR1 variants lead to cerebral calcium-phosphate deposition, which are associated with a neurodegenerative disorder known as primary familial brain calcification (PFBC)<sup>5</sup>. Here, we present the Cryo-EM stru...

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Literature Corpus work: a8774877-8ba1-5f18-9f08-1d56499ed45d
DOI: 10.21203/rs.3.rs-3282549/v1

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