Article

The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

2020-10-17

Abstract excerpt

Transcription factors (TFs) bind DNA sequence motif vocabularies in cis-regulatory elements (CREs) to modulate chromatin state and gene expression during cell state transitions. A quantitative understanding of how motif lexicons influence dynamic regulatory activity has been elusive due to the combinatorial nature of the cis-regulatory code. To address this, we undertook multi-omic data profiling of chromatin and...

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Literature Corpus work: a868d840-b709-5af5-9ee0-0c3565acc67f
DOI: 10.1101/2020.10.16.342857

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