Article

Disease-Linked Regulatory DNA Variants and Homeostatic Transcription Factors in Epidermis

2024-11-11

Abstract excerpt

Identifying noncoding single nucleotide variants ( SNVs ) in regulatory DNA linked to polygenic disease risk, the transcription factors ( TFs ) they bind, and the target genes they dysregulate is a goal in polygenic disease research. Massively parallel reporter gene analysis ( MPRA ) of 3,451 SNVs linked to risk for polygenic skin diseases characterized by disrupted epidermal homeostasis identified 355 differen...

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Literature Corpus work: 37f6c50b-fb1a-5e6d-ae7a-2db4a2d942b0
DOI: 10.1101/2024.11.07.622542

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