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Article

Predicting cell health phenotypes using image-based morphology profiling.

Molecular biology of the cell - 19 Apr 2021

Way Gregory P, Kost-Alimova Maria, Shibue Tsukasa, Harrington William F, Gill Stanley, Piccioni Federica, Becker Tim, Shafqat-Abbasi Hamdah, Hahn William C, Carpenter Anne E, Vazquez Francisca, Singh Shantanu

Abstract excerpt

Genetic and chemical perturbations impact diverse cellular phenotypes, including multiple indicators of cell health. These readouts reveal toxicity and antitumorigenic effects relevant to drug discovery and personalized medicine. We developed two customized microscopy assays, one using four targeted reagents and the other three targeted reagents, to collectively measure 70 specific cell health phenotypes...

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Identifiers

PMID: 33534641
DOI: 10.1091/mbc.E20-12-0784
PMCID: PMC8108524

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