Article

Prophages divert <i>Staphylococcus aureus</i> defenses against host lipids

2022-01-31

Abstract excerpt

Phages are ubiquitous in bacteria, including clinical Staphylococcus aureus , where Sfi 21/Sa3 phages often integrate into the hlb gene, encoding Hlb sphingomyelinase. The integration acts as a rapid regulatory switch of Hlb production. Our findings suggest that Sfi 21/Sa3 prophages and Hlb activity affect S. aureus fitness by modulating the incorporation of the toxic linoleic acid (C18:2) from serum into the b...

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Literature Corpus work: a844fa92-1349-5d65-993d-12fb1dc45510
DOI: 10.1101/2022.01.27.478126

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