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Host-derived fatty acids activate type VII secretion in Staphylococcus aureus

2 Oct 2017

Abstract excerpt

Significance Staphylococcus aureus is one of the most adaptable and prolific human pathogens, and it employs an arsenal of virulence factors to infect blood, bone, and soft tissues. The type VII secretion system (T7SS) is a dedicated virulence protein-secretion pathway that enables long-term survival of the bacteria in abscesses, where they are protected from host immune cells. Here we report that host-derived...

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PMID: 28973946
DOI: 10.1073/pnas.1700627114

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