Article

Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics

2019-05-13

Abstract excerpt

<h4>Summary</h4> Development of fatty acid synthesis pathway (FASII) inhibitors against the major human pathogen Staphylococcus aureus hinges on the accepted but unproven postulate that an endogenously synthesized branched chain fatty acid is required to complete membrane phospholipids. Evidence for anti-FASII efficacy in animal models supported this view. However, restricted test conditions used previously to s...

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Literature Corpus work: 808a5bba-9fcc-5d92-b3c6-36f93eb6d06f
DOI: 10.1101/635698

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