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Article

Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.

Nature communications - 5 Oct 2016

Morvan Claire, Halpern David, Kénanian Gérald, Hays Constantin, Anba-Mondoloni Jamila, Brinster Sophie, Kennedy Sean, Trieu-Cuot Patrick, Poyart Claire, Lamberet Gilles, Gloux Karine, Gruss Alexandra

Abstract excerpt

The bacterial pathway for fatty acid biosynthesis, FASII, is a target for development of new anti-staphylococcal drugs. This strategy is based on previous reports indicating that self-synthesized fatty acids appear to be indispensable for Staphylococcus aureus growth and virulence, although other bacteria can use exogenous fatty acids to compensate FASII inhibition. Here we report that staphylococci can become...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27703138
DOI: 10.1038/ncomms12944
PMCID: PMC5059476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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