Article

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Hexokinase (HK) catalyzes the synthesis of glucose-6-phosphate, marking the first committed step of glucose metabolism. Most cancer cells express two homologous isoforms (HK1 and HK2) that can each bind to the outer mitochondrial membrane (OMM). CRISPR screens across hundreds of cancer cell lines indicate that both are dispensable for cell growth in traditional culture media. By contrast, HK2 d...

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Literature Corpus work: 5008d690-f566-5cf5-9383-b1eebd23284f
DOI: 10.1101/2025.02.07.637120

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