Article

Evaluation of in silico tools and Chat-GPT in identifying the impact of missense variants of immune-related genes associated with immunotherapy outcomes for solid tumors

2024-03-26

Abstract excerpt

Understanding clinical significance of variants of unknown significance (VUS) reported in next-generation sequencing (NGS) has become essential in cancer treatment. Our study examined six widely used in silico tools: PolyPhen-2, Align-GVGD, MutationTaster2, CADD, REVEL, and Chat-GPT. We utilized a dataset of gene variants known to potentially affect immune therapy. No single tool could comprehensively determine mu...

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Literature Corpus work: 49c391d2-fdc4-5d80-9b29-1c7318b62995
DOI: 10.20944/preprints202403.1496.v1

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