Article

A High-Resolution Approach to Mapping Spike Protein Evolution for Advancing Antibody Therapy Design

2025-10-01

Abstract excerpt

<title>Abstract</title> <p>The rapid evolution of SARS-CoV-2 continues to undermine the clinical utility of monoclonal antibody (mAb) therapeutics, with successive viral variants escaping neutralization by previously effective treatments. To proactively identify emerging threats to antibody-based interventions, we conducted a comprehensive global analysis of approximately 9.3 million SARS-CoV-2 spike protein sequ...

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Literature Corpus work: 6d5e43f9-12ea-572e-a1b3-e3d153474cba
DOI: 10.21203/rs.3.rs-7753519/v1

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