Article

Widespread natural selection on metabolite levels in humans

2023-02-07

Abstract excerpt

Natural selection acts ubiquitously on complex human traits, predominantly constraining the occurrence of extreme phenotypes (stabilizing selection). These constrains propagate to DNA sequence variants associated with traits under selection. The genetic imprints of such evolutionary events can thus be detected via combining effect size estimates from genetic association studies and the corresponding allele frequen...

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Literature Corpus work: a7fee595-9328-53a7-9b22-d829f1f9c5f1
DOI: 10.1101/2023.02.07.527420

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