Article

Principles of metabolome conservation in animals

2022-08-15

Abstract excerpt

Metabolite concentrations shape cellular physiology and disease susceptibility, yet the general principles governing metabolome evolution are largely unknown. Here we introduce a measure of conservation of individual metabolite concentrations among related species. By analysing multispecies metabolome datasets in mammals and fruit flies, we show that conservation varies extensively across metabolites. Three major...

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Literature Corpus work: f0197ebf-9018-5e61-a184-6432748e317a
DOI: 10.1101/2022.08.15.503737

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