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Article

Widespread natural selection on metabolite levels in humans.

Genome research - 20 Sept 2024

Timasheva Yanina, Lepik Kaido, Liska Orsolya, Papp Balázs, Kutalik Zoltán

Abstract excerpt

Natural selection acts ubiquitously on complex human traits, predominantly constraining the occurrence of extreme phenotypes (stabilizing selection). These constraints propagate to DNA sequence variants associated with traits under selection. The genetic signatures of such evolutionary events can thus be detected via combining effect size estimates from genetic association studies and the corresponding allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 39152035
DOI: 10.1101/gr.278756.123
PMCID: PMC11444169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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