Human metabolic profiles are stably controlled by genetic and environmental variation.

doi:10.1038/msb.2011.57

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Article

Human metabolic profiles are stably controlled by genetic and environmental variation.

Molecular systems biology - 30 Aug 2011

Nicholson George, Rantalainen Mattias, Maher Anthony D, Li Jia V, Malmodin Daniel, Ahmadi Kourosh R, Faber Johan H, Hallgrímsdóttir Ingileif B, Barrett Amy, Toft Henrik, Krestyaninova Maria, Viksna Juris, Neogi Sudeshna Guha, Dumas Marc-Emmanuel, Sarkans Ugis, The Molpage Consortium, Silverman Bernard W, Donnelly Peter, Nicholson Jeremy K, Allen Maxine, Zondervan Krina T, Lindon John C, Spector Tim D, McCarthy Mark I, Holmes Elaine, Baunsgaard Dorrit, Holmes Chris C

Abstract excerpt

¹H Nuclear Magnetic Resonance spectroscopy (¹H NMR) is increasingly used to measure metabolite concentrations in sets of biological samples for top-down systems biology and molecular epidemiology. For such purposes, knowledge of the sources of human variation in metabolite concentrations is valuable, but currently sparse. We conducted and analysed a study to create such a resource. In our unique design, identical...

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PMID: 21878913
DOI: 10.1038/msb.2011.57
PMCID: PMC3202796

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