Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness

27 May 2014

Abstract excerpt

Metabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Diet and metabolism studies
Share to Metabolomics and Mass Spectrometry Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24866127
DOI: 10.1371/journal.pbio.1001871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical UniquenessPMID 24866127Read ↗

Reduced purine biosynthesis in humans after their divergence from NeandertalsSemantic proximity Read ↗

Principles of metabolome conservation in animalsSemantic proximity Read ↗

Differences in lipidome and metabolome organization of prefrontal cortex among human populations.Semantic proximity Read ↗

Long-term neural and physiological phenotyping of a single human.Semantic proximity Read ↗

Genetic explorations of recent human metabolic adaptations: hypotheses and evidence.Semantic proximity Read ↗

Mapping Inter-Metabolite Relationships in the Human Brain: A Multi-Site, Multi-Modal MRS StudySemantic proximity Read ↗

Comparative lifespan trajectories of brain energy metabolism in human and macaqueSemantic proximity Read ↗

Metabolic changes in human brain evolution.Semantic proximity Read ↗

Convergent relaxation of molecular constraint in mammalian herbivores highlights the roles of liver and kidney functions in carnivorySemantic proximity Read ↗

Human-specific features and developmental dynamics of the brain N-glycomeSemantic proximity Read ↗

Astrocytes Drive Divergent Metabolic Gene Expression in Humans and ChimpanzeesSemantic proximity Read ↗

Astrocytes drive divergent metabolic gene expression in humans and chimpanzeesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.