Article
Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus.
The FEBS journal - 1 Feb 2018
Bousova Kristyna, Herman Petr, Vecer Jaroslav, Bednarova Lucie, Monincova Lenka, Majer Pavel, Vyklicky Ladislav, Vondrasek Jiri, Teisinger Jan
Abstract excerpt
The transient receptor potential channel of melastatin 4 (TRPM4) belongs to a group of large ion receptors that are involved in countless cell signalling cascades. This unique member is ubiquitously expressed in many human tissues, especially in cardiomyocytes, where it plays an important role in cardiovascular processes. Transient receptor potential channels (TRPs) are usually constituted by intracellular N- and...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Binding Sites
- Calmodulin
- Computational Biology
- Conserved Sequence
- Databases, Protein
- Epitopes
- Expert Systems
- Fluorescence Polarization