Article

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity

2025-01-17

Abstract excerpt

Advancements in single-cell technologies and deep sequencing have revealed the vast B-cell repertoire arising from immunisation, enhancing the number of antibodies available for testing. However, selecting the highest affinity antibodies from many sequences is not a straightforward feat, as mechanisms sustaining affinity maturation and related markers remain under-studied. Here, we generated datasets of antigen-sp...

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Literature Corpus work: 65c91d5b-1a3e-5e3a-b406-d3ad7a85a192
DOI: 10.1101/2025.01.15.633143

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