Article

RNA transcripts suppress G-quadruplex structures through G-loop formation

2023-03-10

Abstract excerpt

The eukaryotic genome contains numerous guanine-rich sequences that regulate DNA replication and transcription by folding into non-canonical structures called G-quadruplexes (G4s) 1 . Compromised G4 resolution causes genomic instability and diseases linked to cancer susceptibility and aging 2 . However, how G4s are resolved is poorly understood. G4 structures are found in genomic regions containing DNA:RNA hybri...

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Literature Corpus work: a78b3fc9-2198-5931-a6dc-d19d382db10f
DOI: 10.1101/2023.03.09.531892

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