Integrated multiomic profiling reveals SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities

Abstract excerpt

<h4>Summary</h4> Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex occur in ≈20% of cancers and represent a highly unmet medical need. To identify novel therapeutic approaches, we systematically characterized transcriptomic and proteomic changes caused by the loss of SWI/SNF subunits or other epigenetic enzymes in isogenic cell lines, which we subsequently integrat...

Topics

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• Cancer Mechanisms and Therapy
• Chromatin Assembly and Disassembly
• Chromatin Remodeling and Cancer
• Chromosomal Proteins, Non-Histone
• DNA-Binding Proteins
• Genomics and Chromatin Dynamics
• Neoplasms
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

a77bfa07-c3f4-535d-8e03-21b11c1648d8

DOI

10.1101/2024.07.16.603530